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Comments on: Drink Vinegar and Lose 2-4 Pounds Effortlessly http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/ Ruminations on Weight Loss, Health, and Longevity Via the Mediterranean Diet Fri, 18 May 2012 08:39:37 +0000 http://wordpress.org/?v=2.1.3 By: isaac http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/#comment-16757 isaac Tue, 01 Dec 2009 18:36:26 +0000 http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/#comment-16757 Any ideas as to what the acetic acid may be doing? Any ideas as to what the acetic acid may be doing?

]]> By: Steve Parker, M.D. http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/#comment-16758 Steve Parker, M.D. Tue, 01 Dec 2009 20:25:48 +0000 http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/#comment-16758 The authors cite rat studies in which acetic acid: 1) inhibits lipogenesis, mediated by decreases in gene expression of fatty acid synthase, acetyl-CoA carboxylase, malic enzyme, among others 2) decreases triglycerides by down-regulation of genes for ATP citrate lyase, fatty acid synthase, and acetyl-CoA carboxylase The authors cite rat studies in which acetic acid:

1) inhibits lipogenesis, mediated by decreases in gene expression of fatty acid synthase, acetyl-CoA carboxylase, malic enzyme, among others

2) decreases triglycerides by down-regulation of genes for ATP citrate lyase, fatty acid synthase, and acetyl-CoA carboxylase

]]> By: Steve Parker, M.D. http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/#comment-16916 Steve Parker, M.D. Sat, 12 Dec 2009 02:23:56 +0000 http://advancedmediterraneandiet.com/blog/2009/11/29/drink-vinegar-and-lose-2-4-pounds-effortlessly/#comment-16916 Isaac left a comment I accidentally deleted. But I found it elsewhere: "Huh, I'm curious to know how acetic acid would inhibit de novo fatty acid synthesis. It's just a step away from Acetyl-CoA. Perhaps it's a compartmentalization thing, ie cytosol vs mitochondria. I'm not sure what excess cytolosic acetate would drive towards." Isaac left a comment I accidentally deleted. But I found it elsewhere:

“Huh, I’m curious to know how acetic acid would inhibit de novo fatty acid synthesis. It’s just a step away from Acetyl-CoA. Perhaps it’s a compartmentalization thing, ie cytosol vs mitochondria. I’m not sure what excess cytolosic acetate would drive towards.”

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