Deprecated: Assigning the return value of new by reference is deprecated in /data/15/1/78/151/1404314/user/1507509/htdocs/blog/wp-includes/cache.php on line 36

Deprecated: Assigning the return value of new by reference is deprecated in /data/15/1/78/151/1404314/user/1507509/htdocs/blog/wp-includes/query.php on line 15

Deprecated: Assigning the return value of new by reference is deprecated in /data/15/1/78/151/1404314/user/1507509/htdocs/blog/wp-includes/theme.php on line 505
Comments on: Statin Reduces Heart Attacks, Strokes, and Death in Healthy Older Adults, But at What Cost? http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/ Ruminations on Weight Loss, Health, and Longevity Via the Mediterranean Diet Fri, 18 May 2012 07:54:36 +0000 http://wordpress.org/?v=2.1.3 By: James Hubbard, M.D., M.P.H. http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-127 James Hubbard, M.D., M.P.H. Tue, 11 Nov 2008 01:47:32 +0000 http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-127 Good analysis I heard a well known physician say that every adult should take a statin. It is certainly true that most of the studies have been positive. However, I tend to think whatever comes up must come down. In other words, when everyone starts taking it, we will start hearing about side effects and lawsuits. We already know about the risk of rhabdomyolysis (muscle damage). I think you have to start with healthy diet and exercise. Unfortunately a lot of people want the quick fix. Having said that, I would take a statin if my LDL Cholesterol, or CRP is high, after trying the diet and exercise. Thanks for the info Good analysis
I heard a well known physician say that every adult should take a statin.
It is certainly true that most of the studies have been positive.
However, I tend to think whatever comes up must come down. In other words, when everyone starts taking it, we will start hearing about side effects and lawsuits. We already know about the risk of rhabdomyolysis (muscle damage).
I think you have to start with healthy diet and exercise. Unfortunately a lot of people want the quick fix.
Having said that, I would take a statin if my LDL Cholesterol, or CRP is high, after trying the diet and exercise.

Thanks for the info

]]> By: Steve Parker, M.D. http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-128 Steve Parker, M.D. Tue, 11 Nov 2008 05:24:33 +0000 http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-128 Thanks for your comments, Dr. Hubbard. In the JUPITER study, overall side effects were relatively low, and the study authors thought them quite acceptable in view of the potential benefits. -Steve Thanks for your comments, Dr. Hubbard. In the JUPITER study, overall side effects were relatively low, and the study authors thought them quite acceptable in view of the potential benefits.

-Steve

]]> By: Evelyn Tribole MS RD http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-132 Evelyn Tribole MS RD Tue, 11 Nov 2008 18:12:57 +0000 http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-132 I’d like to see the Mediterranean diet (ala Lyon Diet Heart protocol) go head-to-head with statins. Here's why. First, consider some of the ways that statins work: • Prevents the potent omega-6 fat, arachidonic acid release from the LDL-cholesterol. Arachidonic acid increases blood clots, arrhythmias and stiffens arteries. Arachidonic acid, produces several powerful inflammation that impact cardiovascular health. • Statins also prevent the formation of isoprenoids, another potent group of inflammatory compounds, which are derived from Arachidonic acid. While this might sound like I’m making the case for statins, to the contrary—it’s another reason to eat a Mediterranean diet, which is low in omega-6 fat and high in omega-3 fats. When you lower omega-6 fats, you lower the fuel for inflammation. The higher dietary DHA and EPA (from fish) displaces arachidonic acid from the cell membranes, reducing inflammation further. Let’s also not forget the recent trial where fish oil out-performed statins in patients with chronic heart failure. Lastly, there is compelling evidence from Lyon Diet Heart Trial, which compared eating a Mediterranean-style diet the standard diet recommended by the American Heart Association. After four years on this diet, participants experienced a reduction in all causes of death, including heart disease. The impact of this diet was also reflected in blood phospholipids, with a lower ratio of omega-6 to omega-3 fats. The classic cardiac diet does not distinguish between the types of polyunsaturated fat, which is mostly omega-6 fat and failed to improve the overall prognosis. Evelyn Tribole, MS, RD Sources: de Lorgeril M et al. Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction : Final Report of the Lyon Diet Heart Study Circulation1999;99:779-785 (Free full text) Kim JY et al. Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study. Am J Clin Nutr 2008 88: 630-637. I’d like to see the Mediterranean diet (ala Lyon Diet Heart protocol) go head-to-head with statins. Here’s why.

First, consider some of the ways that statins work:
• Prevents the potent omega-6 fat, arachidonic acid release from the LDL-cholesterol. Arachidonic acid increases blood clots, arrhythmias and stiffens arteries. Arachidonic acid, produces several powerful inflammation that impact cardiovascular health.

• Statins also prevent the formation of isoprenoids, another potent group of inflammatory compounds, which are derived from Arachidonic acid.

While this might sound like I’m making the case for statins, to the contrary—it’s another reason to eat a Mediterranean diet, which is low in omega-6 fat and high in omega-3 fats. When you lower omega-6 fats, you lower the fuel for inflammation. The higher dietary DHA and EPA (from fish) displaces arachidonic acid from the cell membranes, reducing inflammation further. Let’s also not forget the recent trial where fish oil out-performed statins in patients with chronic heart failure.

Lastly, there is compelling evidence from Lyon Diet Heart Trial, which compared eating a Mediterranean-style diet the standard diet recommended by the American Heart Association. After four years on this diet, participants experienced a reduction in all causes of death, including heart disease. The impact of this diet was also reflected in blood phospholipids, with a lower ratio of omega-6 to omega-3 fats. The classic cardiac diet does not distinguish between the types of polyunsaturated fat, which is mostly omega-6 fat and failed to improve the overall prognosis.

Evelyn Tribole, MS, RD

Sources:
de Lorgeril M et al.
Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction : Final Report of the Lyon Diet Heart Study Circulation1999;99:779-785 (Free full text)

Kim JY et al.
Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study. Am J Clin Nutr 2008 88: 630-637.

]]> By: Steve Parker, M.D. http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-136 Steve Parker, M.D. Tue, 11 Nov 2008 20:41:23 +0000 http://advancedmediterraneandiet.com/blog/2008/11/10/statin-reduces-heart-attacks-strokes-and-death-in-healthy-older-adults-but-at-what-cost/#comment-136 Wow. Cogent analysis, as usual, Evelyn. Thanks. -Steve Wow.

Cogent analysis, as usual, Evelyn. Thanks.

-Steve

]]>